Toljanic J A, Ali M, Haraf D J, Vokes E E, Moran W J, Graham L
The University of Chicago, MC-2108, 5841 S. Maryland Avenue, Chicago, IL 60637, USA.
Oncol Rep. 1998 Mar-Apr;5(2):345-9. doi: 10.3892/or.5.2.345.
Osteoradionecrosis of the jaws is a severe complication of radiotherapy in the treatment of the head and neck neoplasms. The literature indicates a recent decline in the reported incidence of this complication. The purpose of this study was to further assess the incidence rate for osteoradionecrosis. Factors previously associated with an increased risk for osteoradionecrosis were evaluated to determine possible relationships. A retrospective chart review was conducted for 193 patients treated with radiotherapy for malignant head and neck tumors over an eight-year period. Recorded diagnoses of osteoradionecrosis were noted. Factors previously correlated with the development of osteoradionecrosis were assessed. Of the 193 charts reviewed, 9 diagnoses of osteoradionecrosis of the jaws were made representing an incidence rate of 4.7% for the period evaluated. No single factor was noted to be associated with the development of osteoradionecrosis. The results indicate a low incidence rate for osteoradionecrosis as a post-radiation treatment complication. No single causative factor could be identified suggesting a multifactorial interaction responsible for osteoradionecrosis.
颌骨放射性骨坏死是头颈部肿瘤放射治疗的一种严重并发症。文献表明，该并发症的报告发病率近期有所下降。本研究的目的是进一步评估放射性骨坏死的发病率。对先前与放射性骨坏死风险增加相关的因素进行评估，以确定可能的关系。对193例在八年期间接受头颈部恶性肿瘤放射治疗的患者进行了回顾性病历审查。记录了放射性骨坏死的诊断情况。评估了先前与放射性骨坏死发生相关的因素。在所审查的193份病历中，有9例被诊断为颌骨放射性骨坏死，在所评估期间的发病率为4.7%。没有发现单一因素与放射性骨坏死的发生有关。结果表明，放射性骨坏死作为放射治疗后并发症的发病率较低。无法确定单一的致病因素，提示放射性骨坏死是由多因素相互作用引起的。
