Prevost A, Nazeyrollas P, Milosevic D, Fernandez-Valoni A
Institut Jean-Godinot, Centre Regional de Lutte Contre le Cancer, Service Chirurgie, 1 Avenue du General Koenig, Reims Cedex, 51056, France.
Oncol Rep. 1998 Mar-Apr;5(2):363-6. doi: 10.3892/or.5.2.363.
Chronic malignant pleural effusion may be treated by instillating products in the pleural space to induce pleurodesis. We used intrapleural doxycycline at doses greater than 2000 mg in 16 malignant pleural effusion (14 patients). Patient survival ranged from 1 day to 19.5 months. Mean drainage duration was 7.5 days (range, 5-10 days). Pain (moderate n=7; severe n=2) was the most frequent side-effect with hypotension (moderate n=3; severe n=1). Five cases were not evaluable at one month because of death during the month following treatment (n=3) or during treatment (n=2). At one month follow-up, success was defined as no pleural effusion (n=5), partial response as minimal effusion (n=4) and we considered that treatment had failed if pleural drainage was necessary (n=2). Five patients died within one month and 5 had more than 3 months survival (4 without recurrence).
慢性恶性胸腔积液可通过向胸腔内注入药物以诱导胸膜固定术来治疗。我们对16例恶性胸腔积液患者（14名患者）使用了剂量超过2000mg的胸腔内强力霉素。患者生存时间从1天到19.5个月不等。平均引流持续时间为7.5天（范围为5 - 10天）。疼痛（中度n = 7；重度n = 2）是最常见的副作用，其次是低血压（中度n = 3；重度n = 1）。5例患者在治疗后1个月无法评估，原因是在治疗后1个月内死亡（n = 3）或在治疗期间死亡（n = 2）。在1个月的随访中，成功定义为无胸腔积液（n = 5），部分缓解定义为少量积液（n = 4），如果需要胸腔引流，我们则认为治疗失败（n = 2）。5例患者在1个月内死亡，5例患者生存超过3个月（4例无复发）。
