Coghill R C, Sang C N, Berman K F, Bennett G J, Iadarola M J
Neurobiology and Anesthesiology Branch, National Institute of Dental Research, Bethesda, Maryland, USA.
J Cereb Blood Flow Metab. 1998 Feb;18(2):141-7. doi: 10.1097/00004647-199802000-00003.
Positron emission tomography studies have identified a common set of brain regions activated by pain. No studies, however, have quantitatively examined pain-induced CBF changes. To better characterize CBF during pain, 14 subjects received positron emission tomography scans during rest, during capsaicin-evoked pain (250 micrograms, intradermal injection), and during innocuous vibration. Using the H215O intravenous bolus method with arterial blood sampling, global CBF changes were assessed quantitatively. Painful stimulation produced a 22.8% decrease in global CBF from resting levels (P < 0.0005). This decrease was not accounted for by arterial PCO2 or heart rate changes. Although the exact mechanism remains to be determined, this pain-induced global decrease represents a previously unidentified response of CBF.
正电子发射断层扫描研究已经确定了一组由疼痛激活的常见脑区。然而，尚无研究对疼痛引起的脑血流量（CBF）变化进行定量检测。为了更好地描述疼痛期间的CBF特征，14名受试者在静息状态、辣椒素诱发疼痛（250微克，皮内注射）以及无害振动期间接受了正电子发射断层扫描。采用静脉注射H215O并进行动脉血采样的方法，对全脑CBF变化进行了定量评估。疼痛刺激使全脑CBF较静息水平降低了22.8%（P < 0.0005）。这种降低并非由动脉血二氧化碳分压或心率变化所致。尽管确切机制尚待确定，但这种疼痛引起的全脑降低代表了一种此前未被识别的CBF反应。
