Flacker J M, Cummings V, Mach J R, Bettin K, Kiely D K, Wei J
Harvard Medical School Division on Aging, Boston, Massachusetts, USA.
Am J Geriatr Psychiatry. 1998 Winter;6(1):31-41.
To investigate the hypothesis that elevated serum anticholinergic activity is independently associated with delirium in ill elderly persons, the authors performed a cross-sectional study of 67 acutely ill older medical inpatients. The presence of delirium was evaluated with the Confusion Assessment Method, and the presence of many delirium symptoms was measured by the Delirium Symptom Interview. Demographic data and clinical characteristics that may be important for the development of delirium were also collected. Logistic regression techniques demonstrated that elevated serum anticholinergic activity was independently associated with delirium. Among the subjects with delirium, a greater number of delirium symptoms was associated with higher serum anticholinergic activity.
为了研究血清抗胆碱能活性升高与老年患者谵妄独立相关这一假设，作者对67名急性病老年内科住院患者进行了一项横断面研究。采用意识模糊评估法评估谵妄的存在情况，通过谵妄症状访谈测量多种谵妄症状的存在情况。还收集了可能对谵妄发生具有重要意义的人口统计学数据和临床特征。逻辑回归技术表明，血清抗胆碱能活性升高与谵妄独立相关。在患有谵妄的受试者中，更多的谵妄症状与更高的血清抗胆碱能活性相关。
