Vega G L, Clark L T, Tang A, Marcovina S, Grundy S M, Cohen J C
The Center for Human Nutrition, Department of Clinical Nutrition, University of Texas Southwestern Medical Center, Dallas 75235-9052, USA.
J Lipid Res. 1998 Jan;39(1):228-32.
Plasma high density lipoprotein cholesterol (HDL-C) concentrations are higher in African American men than in white men, but the mechanism(s) responsible for this ethnic difference has not been elucidated. This study examined the relationship between hepatic lipase activity, plasma HDL-C concentrations, and a hepatic lipase polymorphism (-514T) in African American and white American men. Consistent with previous reports, plasma HDL-C concentrations were significantly higher in African American men than in white American men. Mean post-heparin plasma hepatic lipase activity was significantly lower in African American than in white American men (27 +/- 12 vs. 44 +/- 17 mmol x h(-1) x l(-1), P < 0.001). The -514T hepatic lipase allele was associated with low hepatic lipase activity in both populations, and was 3-fold more common among African Americans than white Americans. Taken together, these data suggest that genetic differences in hepatic lipase activity contribute to the differences in plasma HDL-C concentrations between African American men and white American men.
非裔美国男性的血浆高密度脂蛋白胆固醇（HDL-C）浓度高于白人男性，但造成这种种族差异的机制尚未阐明。本研究调查了非裔美国男性和美国白人男性的肝脂酶活性、血浆HDL-C浓度与肝脂酶多态性（-514T）之间的关系。与之前的报道一致，非裔美国男性的血浆HDL-C浓度显著高于美国白人男性。非裔美国男性肝素后血浆肝脂酶活性均值显著低于美国白人男性（27±12对44±17 mmol·h⁻¹·l⁻¹，P<0.001）。-514T肝脂酶等位基因在两个群体中均与低肝脂酶活性相关，且在非裔美国人中的常见程度是美国白人的3倍。综上所述，这些数据表明肝脂酶活性的遗传差异导致了非裔美国男性和美国白人男性血浆HDL-C浓度的差异。
