Department of Public Health, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands.
PLoS One. 2012;7(8):e43667. doi: 10.1371/journal.pone.0043667. Epub 2012 Aug 20.
To examine ethnic differences in cardiometabolic risk profile in early age, and explore whether such differences can be explained by differences in body mass index (BMI) or waist circumference (WC).
Anthropometric measurements, blood pressure and (in a subsample) fasting blood were collected during a health check of 2,509 children aged 5-6 years. Four ethnic groups were distinguished: Dutch (n=2,008; blood n=1,300), African descent (n=199; blood n=105), Turkish (n=108; blood n=57) and Moroccan (n=194; blood n=94). Ethnic differences in diastolic and systolic blood pressure (DBP/SBP), fasting glucose, low-density lipoprotein (LDL), high-density lipoprotein (HDL) and triglyceride levels were determined and the explanatory role of BMI and WC was examined with regression analysis.
After adjustment for confounders, African descent children showed higher DBP (β2.22 mmHg; 95%CI:1.09-3.36) and HDL levels (β:0.09 mmol/l; 95%CI:0.03-0.16) compared to Dutch children (reference group). Turkish children showed higher SBP (β:1.89 mmHg; 95%CI:0.25-3.54), DBP (β:2.62 mmHg; 95%CI:1.11-4.13), glucose (β:0.12 mmol/L; 95%CI:0.00-0.25) and triglyceride levels (β:0.13 mmol/L; 95%CI:0.02-0.25). Higher BMI values were found in all non-Dutch groups (differences ranged from 0.53-1.03 kg/m(2)) and higher WC in Turkish (β:1.68 cm; 95%CI:0.99-2.38) and Moroccan (β:1.65 cm; 95%CI:1.11-2.19) children. BMI and WC partly explained the higher SBP/DBP and triglyceride levels in Turkish children.
Ethnic differences in cardiometabolic profile exist early in life and are partly explained by differences in BMI and WC. African children showed favourable HDL levels and Turkish children the most unfavourable overall profile, whereas their Moroccan peers have less increased cardiometabolic risk in spite of their high BMI and WC.
为了研究早期不同种族之间心血管代谢风险特征的差异，并探索这些差异是否可以通过体重指数（BMI）或腰围（WC）的差异来解释。
在 2509 名 5-6 岁儿童的健康检查中，收集了人体测量学指标、血压和（在亚组中）空腹血样。区分了四个种族群体：荷兰人（n=2008；血液 n=1300）、非洲裔（n=199；血液 n=105）、土耳其人（n=108；血液 n=57）和摩洛哥人（n=194；血液 n=94）。确定了舒张压和收缩压（DBP/SBP）、空腹血糖、低密度脂蛋白（LDL）、高密度脂蛋白（HDL）和甘油三酯水平的种族差异，并通过回归分析检查了 BMI 和 WC 的解释作用。
在调整了混杂因素后，与荷兰儿童（参考组）相比，非洲裔儿童的 DBP（β2.22mmHg；95%CI：1.09-3.36）和 HDL 水平（β：0.09mmol/L；95%CI：0.03-0.16）更高。土耳其儿童的 SBP（β：1.89mmHg；95%CI：0.25-3.54）、DBP（β：2.62mmHg；95%CI：1.11-4.13）、血糖（β：0.12mmol/L；95%CI：0.00-0.25）和甘油三酯水平（β：0.13mmol/L；95%CI：0.02-0.25）更高。所有非荷兰群体的 BMI 值均较高（差异范围为 0.53-1.03kg/m²），土耳其和摩洛哥儿童的 WC 值较高（β：1.68cm；95%CI：0.99-2.38）和 1.65cm（95%CI：1.11-2.19）。BMI 和 WC 部分解释了土耳其儿童较高的 SBP/DBP 和甘油三酯水平。
心血管代谢特征的种族差异在生命早期就存在，并且部分可以通过 BMI 和 WC 的差异来解释。非洲儿童的 HDL 水平较好，而土耳其儿童的整体情况最差，尽管他们的 BMI 和 WC 较高，但摩洛哥儿童的心血管代谢风险增加较少。
