Deboer Mark D
Department of Pediatrics, Division of Pediatric Endocrinology, University of Virginia School of Medicine, PO Box 800386, Charlottesville, VA 22908, USA Tel.: +1 434 924 9833
Expert Rev Endocrinol Metab. 2011 Mar;6(2):279-289. doi: 10.1586/eem.11.17.
Pediatric obesity threatens the future health of a growing number of children worldwide. An added challenge in identifying the patients at greatest need for intervention due to their elevated risk for future disease is that pediatric obesity and the associated metabolic syndrome manifest differently among different ethnic groups. African-Americans and Hispanics are more likely to exhibit obesity and insulin resistance and are at a higher risk for developing Type 2 diabetes. Nevertheless, using current criteria, African-American adolescents are much less likely to be diagnosed with metabolic syndrome, largely owing to lower rates of dyslipidemia. Further development is needed in ethnicity-inclusive means of risk identification among adolescents to accurately target treatment toward children at highest risk for future disease and to motivate adolescent patients and their families towards lifestyle improvement. Effective targeting and intensive treatment efforts may help in avoiding future sequelae of obesity among all ethnicities.
小儿肥胖症威胁着全球越来越多儿童的未来健康。由于未来疾病风险升高，要确定最需要干预的患者面临的一个额外挑战是，小儿肥胖症及相关代谢综合征在不同种族群体中的表现有所不同。非裔美国人和西班牙裔更有可能出现肥胖和胰岛素抵抗，患2型糖尿病的风险更高。然而，按照目前的标准，非裔美国青少年被诊断为代谢综合征的可能性要小得多，这主要是因为血脂异常的发生率较低。需要进一步发展针对青少年的、包含种族因素的风险识别方法，以便准确地针对未来疾病风险最高的儿童进行治疗，并激励青少年患者及其家人改善生活方式。有效的目标定位和强化治疗措施可能有助于避免所有种族儿童肥胖症的未来后遗症。
