Myint M M, Steinsvoll S, Odden K, Dobloug J, Schenck K
Department of Oral Biology, Dental Faculty, University of Oslo, Norway.
Eur J Oral Sci. 1997 Dec;105(6):562-70. doi: 10.1111/j.1600-0722.1997.tb00218.x.
Levels of total IgA and specific IgA reactive with Streptococcus mutans, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Prevotella nigrescens and Fusobacterium nucleatum were measured by ELISA in parotid saliva from HIV+ and HIV- persons with healthy gingiva (HG), chronic gingivitis, chronic marginal periodontitis (CMP), or necrotizing ulcerative periodontitis (NUP). When the HIV+ group was compared with the HIV- group regardless of periodontal status, total salivary IgA concentration was higher in HIV+ patients, but no such difference was observed for total IgA output. HIV+ CMP displayed higher total IgA concentration as compared with HIV- CMP. No significant differences in specific IgA outputs and ratios were detected between HIV+ and HIV- subgroups with similar periodontal status. HIV+ NUP displayed increased specific IgA output towards S. mutans and increased specific IgA ratio values towards S. mutans, P. gingivalis and P. nigrescens as compared with HIV+ CMP, and increased specific IgA ratio values towards S. mutans and P. nigrescens as compared with HIV+ HG. No such differences were observed between the HIV- subgroups. In sum, salivary IgA responses to bacteria in dental plaque seem not to be related to chronic periodontal disease and HIV infection, but are possibly influenced by acute periodontal infection.
通过酶联免疫吸附测定法（ELISA），检测了HIV阳性和HIV阴性且牙龈健康（HG）、患有慢性牙龈炎、慢性边缘性牙周炎（CMP）或坏死性溃疡性牙周炎（NUP）的人群腮腺唾液中与变形链球菌、伴放线放线杆菌、牙龈卟啉单胞菌、中间普氏菌、变黑普氏菌和具核梭杆菌反应的总IgA和特异性IgA水平。无论牙周状况如何，将HIV阳性组与HIV阴性组进行比较时，HIV阳性患者唾液中总IgA浓度较高，但总IgA分泌量未观察到此类差异。与HIV阴性CMP相比，HIV阳性CMP的总IgA浓度更高。在牙周状况相似的HIV阳性和HIV阴性亚组之间，未检测到特异性IgA分泌量和比率的显著差异。与HIV阳性CMP相比，HIV阳性NUP对变形链球菌的特异性IgA分泌量增加，对变形链球菌、牙龈卟啉单胞菌和变黑普氏菌的特异性IgA比率值增加；与HIV阳性HG相比，对变形链球菌和变黑普氏菌的特异性IgA比率值增加。在HIV阴性亚组之间未观察到此类差异。总之，唾液中针对牙菌斑细菌的IgA反应似乎与慢性牙周病和HIV感染无关，但可能受急性牙周感染影响。
