Steinsvoll S, Myint M, Odden K, Berild D, Schenck K
Department of Oral Biology, University of Oslo, Norway.
J Clin Periodontol. 1997 Nov;24(11):823-9. doi: 10.1111/j.1600-051x.1997.tb01196.x.
Serum samples were obtained from 44 HIV-seropositive (HIV+) and 37 HIV-seronegative (HIV-) persons that were grouped according to periodontal status. Serum IgG and IgA reactivities towards Streptococcus mutans, Actinobacillus actinomycetemcomitans, Porphyromonas gingivalis. Prevotella intermedia, Prevotella nigrescens and Fusobacterium nucleatum were measured by means of ELISA. HIV+ persons with chronic marginal periodontitis showed significantly lower IgG reactivities to the periodontal pathogens A. actinomycetemcomitans, P. gingivalis, P. intermedia and F. nucleatum as compared with their HIV- counterparts (p < 0.05). Specific serum IgA reactivities were similar in the two periodontitis groups, except for P. nigrescens where the HIV+ group with chronic marginal periodontitis had lower values than their systemically healthy counterparts (p < 0.05). The results indicate that HIV infection affects the humoral serum immune responses against bacteria in dental plaque; the depressed antibody responses may contribute to the increased susceptibility for periodontal infections in HIV-infected patients.
从44名HIV血清阳性（HIV+）和37名HIV血清阴性（HIV-）的个体中获取血清样本，并根据牙周状况进行分组。采用酶联免疫吸附测定法（ELISA）检测血清中针对变形链球菌、伴放线放线杆菌、牙龈卟啉单胞菌、中间普氏菌、变黑普氏菌和具核梭杆菌的IgG和IgA反应性。与HIV-个体相比，患有慢性边缘性牙周炎的HIV+个体对牙周病原体伴放线放线杆菌、牙龈卟啉单胞菌、中间普氏菌和具核梭杆菌的IgG反应性显著降低（p<0.05）。除变黑普氏菌外，两个牙周炎组的特异性血清IgA反应性相似，在变黑普氏菌检测中，患有慢性边缘性牙周炎的HIV+组的值低于全身健康的对照组（p<0.05）。结果表明，HIV感染会影响针对牙菌斑中细菌的体液血清免疫反应；抗体反应降低可能导致HIV感染患者牙周感染易感性增加。
