Smith R E
Allegheny University of Health Sciences, Pittsburgh, Pennsylvania, USA.
Semin Thromb Hemost. 1997;23(6):547-9. doi: 10.1055/s-2007-996134.
The use of oral anticoagulants to treat and prevent thromboembolic disease has been a major medical development and has largely been made practicable by the introduction of the prothrombin time as a method for monitoring patients during therapy. Unfortunately, despite many years of application, the administration of oral anticoagulants is still fraught with complications. This has been partly a consequence of the absence of a uniform method of performing and comparing prothrombin times from one laboratory to another. One attempt to solve this problem has been the introduction of the International Sensitivity Index (ISI) and the International Normalized Ratio (INR) as applied to the prothrombin time. The objectives of this article are to (1) explain the need for and development of the INR, (2) discuss shortcomings of the INR and common misinterpretations, and (3) present easy ways to correct for the identified shortcomings.
使用口服抗凝剂治疗和预防血栓栓塞性疾病是医学上的一项重大进展，而凝血酶原时间作为治疗期间监测患者的一种方法，很大程度上使得口服抗凝剂的使用变得可行。不幸的是，尽管应用多年，但口服抗凝剂的使用仍充满并发症。部分原因是缺乏一种统一的方法来在不同实验室之间进行凝血酶原时间的检测和比较。解决这一问题的一种尝试是引入应用于凝血酶原时间的国际敏感指数（ISI）和国际标准化比值（INR）。本文的目的是：（1）解释INR的必要性和发展历程；（2）讨论INR的缺点和常见误解；（3）介绍纠正已发现缺点的简便方法。
