Kase Y, Hayakawa T, Aburada M, Komatsu Y, Kamataki T
Central Research Laboratories, Tsumura & Co., Inashiki-gun, Ibaraki, Japan.
Jpn J Pharmacol. 1997 Dec;75(4):407-13. doi: 10.1254/jjp.75.407.
The possible preventive effect of Kampo medicine Hange-shashin-to (TJ-14) on chronic diarrheal symptoms induced by the administration of the anticancer agent irinotecan hydrochloride (CPT-11) was investigated in the rat. Repeated oral administrations of TJ-14 at 125 and 500 mg/kg significantly prevented the reduction in body weight and the onset of chronic diarrheal symptoms due to CPT-11 in a dose-dependent manner, even though it failed to show a definite effect on acute diarrheal symptoms. In addition, treatment with TJ-14 accelerated the healing of the intestinal tract injured by repeated dosing of CPT-11 and inhibited significantly the increase of colonic prostaglandin E2 (PGE2) which is closely related to the onset of diarrhea. TJ-14 also improved colonic water absorption impaired by repeated dosing of CPT-11 in rats. These results demonstrate that TJ-14 is an effective medicine for the prevention and/or treatment of CPT-11-induced chronic diarrheal symptoms.
在大鼠中研究了汉方药物半夏泻心汤（TJ - 14）对抗癌药物盐酸伊立替康（CPT - 11）所致慢性腹泻症状的可能预防作用。以125和500mg/kg的剂量反复口服TJ - 14，虽对急性腹泻症状未显示出确切效果，但能以剂量依赖的方式显著预防CPT - 11所致的体重减轻和慢性腹泻症状的发生。此外，TJ - 14治疗加速了因反复给予CPT - 11而受损的肠道愈合，并显著抑制了与腹泻发生密切相关的结肠前列腺素E2（PGE2）的增加。TJ - 14还改善了大鼠因反复给予CPT - 11而受损的结肠水吸收。这些结果表明，TJ - 14是预防和/或治疗CPT - 11所致慢性腹泻症状的有效药物。
