Shanghai University of Traditional Chinese Medicine, Shanghai, China.
Medicine (Baltimore). 2023 Sep 1;102(35):e34891. doi: 10.1097/MD.0000000000034891.
Banxia Xiexin decoction (BXD), a famous traditional Chinese prescription constituted by Pinelliae Rhizoma, Zingiberis Rhizoma, Scutellariae Radix, Coptidis Rhizoma, Ginseng Radix et Rhizoma, Jujubae Fructus and Glycyrrhizae Radix et Rhizoma Praeparata Cum Mell, has notable characteristics of acrid-opening, bitter down-bearing and sweet-tonification, interfering with tumors, gastrointestinal diseases, central nervous system diseases and much more. Based on the wide clinical applications, current investigations of BXD focused on several aspects: chemical analysis to explore the underlying substrates responsible for the therapeutic effects; basic studies on pharmacological actions of the whole prescription or of those representative ingredients to demonstrate the intriguing molecular targets for specific pathological processes; pharmacokinetic feature studies of single or all components of BXD to reveal the chemical basis and synergistic actions contributing to the pharmacological and clinically therapeutic effects. In this review, we summarized the main achievements of phytochemical, pharmacological, clinical and pharmacokinetic profiles of BXD and its herbal or pharmacologically active chemicals, as well as discussions of our understanding which further reveals the significance of BXD clinically.
半夏泻心汤（BXD）是一种著名的中药方剂，由半夏、生姜、黄芩、黄连、人参、大枣和炙甘草组成，具有辛开苦降、甘补和中的特点，可用于治疗肿瘤、胃肠道疾病、中枢神经系统疾病等多种疾病。基于其广泛的临床应用，目前对 BXD 的研究主要集中在以下几个方面：化学分析以探索负责治疗效果的潜在基础；对全方或代表性成分的药理作用进行基础研究，以揭示针对特定病理过程的有趣分子靶点；对 BXD 的单个或所有成分的药代动力学特征进行研究，以揭示有助于药理和临床治疗效果的化学基础和协同作用。在本文中，我们总结了 BXD 及其草药或具有药理活性的化学成分的植物化学、药理学、临床和药代动力学特征的主要成就，并讨论了我们对其的理解，这进一步揭示了 BXD 在临床上的重要意义。
