Brown L A, Levin G M
Department of Pharmacy Practice, Albany College of Pharmacy, NY 12208-3492, USA.
Pharmacotherapy. 1998 Jan-Feb;18(1):69-83.
The introduction of antipsychotics for the management of schizophrenia greatly improved the quality of life of many patients suffering from this debilitating disease. Although typical antipsychotic drugs represent a significant advancement in psychopharmacology, they carry a heavy side effect burden, have little efficacy in the management of negative symptoms, and are ineffective in about one-third of patients with schizophrenia. Atypical antipsychotic agents characterized the next major advancement in pharmacotherapy. They differ from typical antipsychotics in their mechanism of action, side effect profiles, and clinical efficacy. Sertindole is a new atypical antipsychotic.
使用抗精神病药物治疗精神分裂症极大地改善了许多患有这种使人衰弱疾病的患者的生活质量。尽管传统抗精神病药物是精神药理学的一项重大进展，但它们具有严重的副作用负担，对阴性症状的治疗效果不佳，并且对约三分之一的精神分裂症患者无效。非典型抗精神病药物代表了药物治疗的下一个重大进展。它们在作用机制、副作用谱和临床疗效方面与传统抗精神病药物不同。舍吲哚是一种新型非典型抗精神病药物。
