McDevitt J T, Gurst A H, Chen Y
MEDEX Clinical Trial Services, Inc., Ardmore, Pennsylvania 19003, USA.
Pharmacotherapy. 1998 Jan-Feb;18(1):193-7.
We attempted to determine the accuracy of manually splitting hydrochlorothiazide tablets. Ninety-four healthy volunteers each split ten 25-mg hydrochlorothiazide tablets, which were then weighed using an analytical balance. Demographics, grip and pinch strength, digit circumference, and tablet-splitting experience were documented. Subjects were also surveyed regarding their willingness to pay a premium for commercially available, lower-dose tablets. Of 1752 manually split tablet portions, 41.3% deviated from ideal weight by more than 10% and 12.4% deviated by more than 20%. Gender, age, education, and tablet-splitting experience were not predictive of variability. Most subjects (96.8%) stated a preference for commercially produced, lower-dose tablets, and 77.2% were willing to pay more for them. For drugs with steep dose-response curves or narrow therapeutic windows, the differences we recorded could be clinically relevant.
我们试图确定手动掰开氢氯噻嗪片的准确性。94名健康志愿者每人掰开10片25毫克的氢氯噻嗪片，然后用分析天平称重。记录了人口统计学信息、握力和捏力、手指周长以及片剂掰开经验。还对受试者进行了调查，询问他们是否愿意为市售的低剂量片剂支付额外费用。在1752个手动掰开的片剂部分中，41.3%偏离理想重量超过10%，12.4%偏离超过20%。性别、年龄、教育程度和片剂掰开经验并不能预测变异性。大多数受试者（96.8%）表示更喜欢商业生产的低剂量片剂，77.2%愿意为此支付更多费用。对于具有陡峭剂量反应曲线或窄治疗窗的药物，我们记录的差异可能具有临床相关性。
