年轻非肥胖日本男性中高胰岛素血症的患病率。

Prevalence of hyperinsulinemia in young, nonobese Japanese men.

作者信息

Masuo K, Mikami H, Ogihara T, Tuck M L

机构信息

Department of Geriatric Medicine, Osaka University Medical School, Suita, Japan.

出版信息

J Hypertens. 1997 Feb;15(2):157-65. doi: 10.1097/00004872-199715020-00006.

DOI:10.1097/00004872-199715020-00006

PMID:9469791

Abstract

OBJECTIVE

To clarify the prevalence of hyperinsulinemic subjects among young, nonobese, Japanese men, and to evaluate characteristics, in particular, of sympathetic nerve system activity and lipid fractions in hyperinsulinemic subjects.

METHODS

Norepinephrine, plasma insulin, and lipid fractions were measured in 512 normotensive, 124 borderline hypertensive (BHT) and 88 established hypertensive (EHT) subjects, matched for age and body mass index, after they had fasted overnight.

RESULTS

Hyperinsulinemia defined as mean fasting plasma insulin + 2SD in normotensives or more was found in 8% of all subjects (normotensive and hypertensive subjects, P = 0.018), 6% of normotensives, 10% of BHT (P = 0.28, versus normotensives), 18% of EHT (P = 0.005, versus normotensives), and 12% of hypertensives (P = 0.019, versus normotensives). The hyperinsulinemic (fasting insulin > or = mean + 2SD in normotensive) subjects had higher plasma norepinephrine levels in all blood pressure groups than did nonhyperinsulinemic (< mean + 2SD) subjects (normotensives P < 0.05, BHT P < 0.01, and EHT P < 0.05). Hyperinsulinemic normotensives had higher blood pressure levels than did nonhyperinsulinemic ones (P < 0.05); however, blood pressure levels in hyperinsulinemic BHT and EHT were similar to those in nonhyperinsulinemic subjects. Triglyceride in BHT and EHT was greater than that in normotensives (P < 0.05), and that in hyperinsulinemic subjects was greater than that in nonhyperinsulinemic subjects (P < 0.05). On the other hand, high-density lipoprotein cholesterol in hyperinsulinemic BHT and EHT was significantly lower than that in nonhyperinsulinemic BHT (P < 0.05) and EHT (P < 0.01).

CONCLUSION

These results demonstrated that the prevalence of hyperinsulinemia among the present sample of young, nonobese, Japanese men was 12% and that the prevalence increased with blood pressure elevation. Furthermore, hypertriglyceridemia and sympathetic nerve hyperactivity appear to be related to hyperinsulinemia and the emergence of hypertension.

摘要

目的

明确年轻、非肥胖日本男性中高胰岛素血症患者的患病率，并评估高胰岛素血症患者的特征，尤其是交感神经系统活性和血脂成分。

方法

对512名血压正常、124名临界高血压（BHT）和88名确诊高血压（EHT）患者在过夜禁食后测量去甲肾上腺素、血浆胰岛素和血脂成分，这些患者年龄和体重指数相匹配。

结果

以血压正常者的空腹血浆胰岛素均值+2SD及以上定义为高胰岛素血症，在所有受试者（血压正常和高血压患者）中占8%（P = 0.018），血压正常者中占6%，BHT患者中占10%（与血压正常者相比，P = 0.28），EHT患者中占18%（与血压正常者相比，P = 0.005），高血压患者中占12%（与血压正常者相比，P = 0.019）。在所有血压组中，高胰岛素血症（空腹胰岛素≥血压正常者均值+2SD）患者的血浆去甲肾上腺素水平均高于非高胰岛素血症（<均值+2SD）患者（血压正常者P < 0.05，BHT患者P < 0.01，EHT患者P < 0.05）。高胰岛素血症的血压正常者血压水平高于非高胰岛素血症者（P < 0.05）；然而，高胰岛素血症的BHT和EHT患者血压水平与非高胰岛素血症患者相似。BHT和EHT患者的甘油三酯水平高于血压正常者（P < 0.05），高胰岛素血症患者的甘油三酯水平高于非高胰岛素血症患者（P < 0.05）。另一方面，高胰岛素血症的BHT和EHT患者的高密度脂蛋白胆固醇显著低于非高胰岛素血症的BHT患者（P < 0.05）和EHT患者（P < 0.01）。