Kesseler H J, Grier W R, Seidman I, McIlveen S J
JAMA. 1976 Jul 19;236(3):278-80.
Primary carcinoma of breast was treated in 967 patients from 1962 through 1972. Thirty-five of these patients had a second primary tumor of which 50% were discovered simultaneously. A family history for cancer was recorded in 26% of the patients with bilateral cancer. Patients found their tumor more often than the physician except in the simultaneous cases where the physician was more successful. Pathological examination showed 10% of the tumors were comedo, lobular carcinoma in situ, papillary, or tubular cancers. In the metachronous group, 50% of the axillae were involved on both sides. In the simultaneous cases the axilla was less frequently involved. Mammography, biopsies of the second breast, and prophylactic mastectomy in certain high-risk patients should improve survival rates.
1962年至1972年间，对967例原发性乳腺癌患者进行了治疗。其中35例患者患有第二种原发性肿瘤，其中50%是同时发现的。在双侧癌症患者中，26%有癌症家族史。除了在医生发现更成功的同时性病例外，患者发现自己肿瘤的情况比医生更常见。病理检查显示，10%的肿瘤为粉刺癌、原位小叶癌、乳头状癌或管状癌。在异时性组中，双侧腋窝均受累的占50%。在同时性病例中，腋窝受累的频率较低。乳房X线摄影、对侧乳房活检以及对某些高危患者进行预防性乳房切除术应能提高生存率。
