Smith E B
J Natl Med Assoc. 1986 Nov;78(11):1069-72.
At the St. Francis Medical Center during the 20-year period 1960-1980, there were 1,148 primary breast cancers with a 7.1 percent incidence of synchronous and metachronous invasive primary breast cancer. Twenty-one cases (1.8 percent of the total series) illustrate noninvasive cancer of the breast. The essential approaches toward the diagnosis of a contralateral cancer were breast self-examination, history and physical examination, and x-ray mammography. Biopsy of contralateral discrete breast masses was advocated. If biopsies were positive for malignancy, definitive surgical management with indicated supplemental oncological therapy were recommended. "Blind focal biopsy" of the contralateral breast was discouraged. The five- to 25-year disease-free survival rate for 82 invasive bilateral breast cancers was 51 percent with a follow-up percentage of 98 percent during an interval of five to ten years. The survival statistics in the primary bilateral breast cancers when compared to results in primary unilateral breast cancers were not as grave as anticipated.
在1960年至1980年的20年期间，圣弗朗西斯医疗中心有1148例原发性乳腺癌，同时性和异时性浸润性原发性乳腺癌的发病率为7.1%。21例（占总病例数的1.8%）为乳腺非浸润性癌。诊断对侧乳腺癌的基本方法包括乳房自我检查、病史和体格检查以及乳房X线摄影。提倡对侧乳房孤立性肿块进行活检。如果活检结果为恶性阳性，则建议进行明确的手术治疗并辅以适当的肿瘤治疗。不鼓励对侧乳房进行“盲目局灶活检”。82例浸润性双侧乳腺癌的5至25年无病生存率为51%，在5至10年的随访期内随访率为98%。与原发性单侧乳腺癌的结果相比，原发性双侧乳腺癌的生存统计数据并不像预期的那么严重。
