Chotmongkol V, Sukeepaisarncharoen W
Department of Medicine, Faculty of Medicine, Khon Kaen University, Thailand.
J Med Assoc Thai. 1997 Dec;80(12):767-70.
We conducted a prospective, open trial to establish the efficacy of itraconazole 400 mg/d as maintenance treatment for cryptococcal meningitis in AIDS patients. Between February 1996 and May 1997, 50 patients were included for analysis. After a mean follow-up of 326 days, 2 of 38 patients (5.3 per cent) had relapses of symptomatic cryptococcal meningitis. Hepatotoxicity occurred in 2 cases. In conclusion, maintenance therapy with itraconazole 400 mg/d is effective in preventing recurrent cryptococcal meningitis.
我们进行了一项前瞻性开放试验，以确定伊曲康唑400mg/d作为艾滋病患者隐球菌性脑膜炎维持治疗的疗效。1996年2月至1997年5月，纳入50例患者进行分析。平均随访326天后，38例患者中有2例（5.3%）出现有症状的隐球菌性脑膜炎复发。2例出现肝毒性。总之，伊曲康唑400mg/d维持治疗可有效预防复发性隐球菌性脑膜炎。
