Creamer D, Jaggar R, Allen M, Bicknell R, Barker J
St John's Institute of Dermatology, UMDS, London, U.K.
Br J Dermatol. 1997 Dec;137(6):851-5.
Considerable evidence indicates that the microvascular changes observed in psoriasis are a result of angiogenesis. Vascular proliferation is driven by the local production of molecules which have angiogenic activity. Platelet-derived endothelial cell growth factor/thymidine phosphorylase (PDECGF/TP) is a potent angiogenic factor active in in vivo angiogenesis assays and overexpressed in several tumour types. We have demonstrated by ribonuclease protection analysis a consistently high degree of PDECGF/TP mRNA production in lesional psoriatic skin, while immunohistochemical studies revealed strong PDECGF/TP immunoreactivity in lesional epidermis, with nuclear staining present in basal keratinocytes and cytoplasmic immunoreactivity in suprabasal layers. Non-lesional skin showed minimal PDECGF/TP mRNA production and weak epidermal immunostaining. These results indicate a potential role for PDECGF/TP in the pathophysiology of psoriasis, and reveal a target for antiangiogenesis therapy in the treatment of this disease.
大量证据表明，银屑病中观察到的微血管变化是血管生成的结果。血管增殖由具有血管生成活性的分子的局部产生所驱动。血小板衍生的内皮细胞生长因子/胸苷磷酸化酶（PDECGF/TP）是一种在体内血管生成试验中具有活性的强效血管生成因子，在几种肿瘤类型中过表达。我们通过核糖核酸酶保护分析证明，在银屑病皮损皮肤中，PDECGF/TP mRNA的产生始终处于较高水平，而免疫组织化学研究显示，皮损表皮中PDECGF/TP免疫反应性较强，基底角质形成细胞中有核染色，基底层以上各层有细胞质免疫反应性。非皮损皮肤显示PDECGF/TP mRNA产生极少，表皮免疫染色较弱。这些结果表明PDECGF/TP在银屑病病理生理学中具有潜在作用，并揭示了抗血管生成疗法在治疗该疾病中的一个靶点。
