Leong Tai Teck, Fearon Ursula, Veale Douglas J
Department of Rheumatology, St. Vincent's University Hospital and The Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Dublin 4, Ireland.
Curr Rheumatol Rep. 2005 Aug;7(4):325-9. doi: 10.1007/s11926-005-0044-5.
Psoriasis is a common chronic dermatosis occurring in 2% of the population and associated with an inflammatory arthritis--psoriatic arthritis (PsA)--in up to 40% of cases. PsA accounts for approximately 15% of patients attending early synovitis clinics, therefore it represents the second most common diagnostic category after rheumatoid arthritis. There are a number of common pathogenic features that link the skin and the joint inflammatory processes. Angiogenesis appears to be a fundamental inflammatory response early in the pathogenesis and significant abnormalities of vascular morphology and angiogenic growth factors have been described in psoriasis and PsA. This paper will explore the recent published evidence to support the hypothesis that dysregulated angiogenesis provides a primary pathogenic mechanism in psoriasis skin and in the PsA joint.
银屑病是一种常见的慢性皮肤病，发病率为2%，在高达40%的病例中与炎性关节炎——银屑病关节炎（PsA）相关。PsA约占早期滑膜炎门诊患者的15%，因此它是仅次于类风湿关节炎的第二常见诊断类型。皮肤和关节的炎症过程存在许多共同的致病特征。血管生成似乎是发病机制早期的一种基本炎症反应，银屑病和PsA中已描述了血管形态和血管生成生长因子的显著异常。本文将探讨最近发表的证据，以支持血管生成失调是银屑病皮肤和PsA关节主要致病机制这一假说。
