[西波希米亚地区侵袭性脑膜炎球菌病的临床和流行病学特征变化与脑膜炎奈瑟菌侵袭性克隆株的出现相关]

[Changes in clinical and epidemiologic characteristics in Western Bohemia of invasive meningococcal disease associated with the occurrence of an invasive clone of Neisseria meningitidis].

作者信息

Struncová V, Pazdiora P, Valchová M, Sedlácek D, Fránová D, Bárta R, Musílek M, Krízová P

机构信息

Infekcní klinika, Fakultní nemocnice, Plzen.

出版信息

Epidemiol Mikrobiol Imunol. 1997 Dec;46(4):145-8.

PMID:9471304

Abstract

The authors analyzed the incidence of meningococcal diseases in the West Bohemian region in 1982-1996. The draw attention to changes of clinical and epidemiological characteristics of the disease which appeared in 1994 in conjunction with a new invasive clonus of Neisseria meningitidis C:2a:P1.2, P1.5, ET-15/37. While in 1982-1993 invasive meningococcal diseases had in 75% the course of meningitis with a relatively low fatality (4%), during the subsequent period a marked change occurred. Since 1994 the disease took in the West Bohemian region in 58% the course of sepsis with a fatality of 16%. 25% cases of meningococcal meningitis were diagnosed combined sepsis and meningitis in 17%. The disease lost its seasonal character and the authors confirmed the highest incidence of the disease in the age group from 15-19 years and 0-4 years. Neisseria meningitidis group C was detected in 1994-1996 in 73% and the invasive clone C:2a:P1.2, P1.5, ET-15/37 in 62%.

摘要

作者分析了1982 - 1996年西波希米亚地区脑膜炎球菌病的发病率。他们提请注意该疾病在1994年出现的临床和流行病学特征变化，这与一种新的侵袭性脑膜炎奈瑟菌C群：2a：P1.2、P1.5、ET - 15/37克隆有关。在1982 - 1993年期间，侵袭性脑膜炎球菌病75%表现为脑膜炎病程，病死率相对较低（4%），而在随后的时期发生了显著变化。自1994年以来，西波希米亚地区该疾病58%表现为败血症病程，病死率为16%。25%的脑膜炎球菌性脑膜炎病例被诊断为合并败血症，17%为合并脑膜炎。该疾病失去了季节性特征，作者证实该疾病在15 - 19岁和0 - 4岁年龄组发病率最高。1994 - 1996年期间，73%检测到脑膜炎奈瑟菌C群，62%检测到侵袭性克隆C：2a：P1.2、P1.5、ET - 15/37。