2001年捷克共和国血清学调查——侵袭性脑膜炎球菌病
The 2001 serological survey in the Czech Republic--invasive meningococcal disease.
作者信息
Krízová P
机构信息
National Reference Laboratory for Meningococcal Infections, National Institute of Public Health, Prague, Czech Republic.
出版信息
Cent Eur J Public Health. 2003 Dec;11 Suppl:S62-7.
In 2001, 730 sera from the population of 14 areas of the Czech Republic aged between 1 and 64 years were tested by a microplate assay for the presence of bactericidal antibodies against N. meningitidis A:4,21:P1. 10, N. meningitidis B:2a:P1.2,P1.5 and N. meningitidis C:2a:P1.2,P1.5. The Czech population showed high immunity against N. meningitidis A:4,21:P1.10, but low immunity against N. meningitidis B:2a:P1.2,P1.5 and N. meningitidis C:2a:P1.2,P1.5. The current epidemiological situation requires neither vaccination against meningococcus A nor inclusion of conjugated vaccine against meningococcus C into routine vaccination. Nevertheless, the invasive meningococcal disease surveillance programme needs to be continued since enabling rapid detection of possible changes in the epidemiological situation and subsequent vaccination intervention, if epidemiologically indicated. Conjugated vaccine against meningococcus C should replace polysaccharide vaccine A+C in all indications currently relevant in the Czech Republic.
2001年，采用微孔板分析法对捷克共和国14个地区年龄在1至64岁之间的730份血清进行检测，以确定是否存在针对A群脑膜炎奈瑟菌4,21:P1.10、B群脑膜炎奈瑟菌2a:P1.2、P1.5和C群脑膜炎奈瑟菌2a:P1.2、P1.5的杀菌抗体。捷克人群对A群脑膜炎奈瑟菌4,21:P1.10具有较高免疫力，但对B群脑膜炎奈瑟菌2a:P1.2、P1.5和C群脑膜炎奈瑟菌2a:P1.2、P1.5免疫力较低。当前的流行病学形势既不需要接种A群脑膜炎球菌疫苗，也不需要将C群脑膜炎球菌结合疫苗纳入常规疫苗接种。然而，侵袭性脑膜炎球菌病监测计划仍需继续，以便能够快速发现流行病学形势的可能变化，并在流行病学指征明确时进行后续疫苗接种干预。在捷克共和国目前所有相关适应证中，C群脑膜炎球菌结合疫苗应取代A+C多糖疫苗。
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