Coeugniet E, Bendixen G
Acta Allergol. 1976 Apr;31(2):94-106.
Supernatants from Con-A stimulated human lymphocytes containing leucocyte migration inhibitory activity were measured for thrombocyte aggregation activity and for influence on thrombocyte rich plasma clot retraction and whole blood clot retraction. The lymphocyte released activity of the supernatants produced thrombocyte aggregation and an acceleration of clot retraction. The activity resisted heating at 56 degrees C for 30 min and was inactivated at 80 degrees C for 30 min. The active substance seems to have a molecular weight above 10,000 daltons. The findings suggest that thrombotic processes associated with cell-mediated (type IV) immune inflammation could be due, at least partially, to lymphokine effects on thrombocytes.
对来自刀豆蛋白A刺激的人淋巴细胞的上清液进行检测，测定其血小板聚集活性以及对富含血小板血浆凝块回缩和全血凝块回缩的影响。上清液中淋巴细胞释放的活性物质可产生血小板聚集并加速凝块回缩。该活性在56℃加热30分钟后仍能保留，但在80℃加热30分钟则会失活。活性物质的分子量似乎高于10,000道尔顿。这些发现表明，与细胞介导的（IV型）免疫炎症相关的血栓形成过程可能至少部分归因于淋巴因子对血小板的作用。
