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豚鼠淋巴细胞培养上清液中的5-羟色胺释放活性。

5-Hydroxytryptamine releasing activity in culture supernatants of guinea pig lymphocytes.

作者信息

Hagen M, Paegelow I, Karnstedt U

出版信息

Agents Actions. 1984 Oct;15(3-4):264-6. doi: 10.1007/BF01972360.

DOI:10.1007/BF01972360
PMID:6240929
Abstract

5-Hydroxytryptamine (5-HT) is not only involved in anaphylactic reactions but also in delayed-type hypersensitivity (DTH) reactions. Supernatants of cultivated guinea pig spleen lymphocytes were investigated for possessing 5-HT releasing activity. Both fractionated supernatants of mixed lymphocytes unspecifically stimulated by Concanavalin A (Con A) and fractionated supernatants of non-stimulated mixed lymphocytes decrease the 5-HT content of rabbit thrombocytes. Fractions of a molecular weight smaller than 12,500 daltons are more effective than fractions of a higher molecular weight range. The 5-HT releasing activity of the supernatants is discussed in comparison to a cell migration stimulating activity.

摘要

5-羟色胺（5-HT）不仅参与过敏反应，还参与迟发型超敏反应（DTH）。对培养的豚鼠脾脏淋巴细胞的上清液进行了研究，以确定其是否具有5-HT释放活性。用伴刀豆球蛋白A（Con A）非特异性刺激的混合淋巴细胞分级上清液和未刺激的混合淋巴细胞分级上清液均可降低兔血小板的5-HT含量。分子量小于12,500道尔顿的级分比分子量较高范围的级分更有效。将上清液的5-HT释放活性与细胞迁移刺激活性进行了比较讨论。

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引用本文的文献

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Agents Actions. 1984 Oct;15(3-4):361-6. doi: 10.1007/BF01972372.
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Biological characterization of guinea pig lymphotoxin production.豚鼠淋巴毒素产生的生物学特性
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J Immunol. 1977 Jan;118(1):159-65.