癌症中的泛素-蛋白酶体途径。
The ubiquitin-proteasome pathway in cancer.
作者信息
Spataro V, Norbury C, Harris A L
机构信息
Imperial Cancer Research Fund, University of Oxford, Institute of Molecular Medicine, The John Radcliffe, UK.
出版信息
Br J Cancer. 1998;77(3):448-55. doi: 10.1038/bjc.1998.71.
Abstract
Degradation by the 26S proteasome of specific proteins that have been targeted by the ubiquitin pathway is the major intracellular non-lysosomal proteolytic mechanism and is involved in a broad range of processes, such as cell cycle progression, antigen presentation and control of gene expression. Recent work, reviewed here, has shown that this pathway is often the target of cancer-related deregulation and can underlie processes, such as oncogenic transformation, tumour progression, escape from immune surveillance and drug resistance.
摘要
泛素途径靶向的特定蛋白质经26S蛋白酶体降解是细胞内主要的非溶酶体蛋白水解机制，参与广泛的过程，如细胞周期进程、抗原呈递和基因表达调控。本文综述的近期研究表明，该途径常常是癌症相关失调的靶点，并且可能是致癌转化、肿瘤进展、逃避免疫监视和耐药性等过程的基础。
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