Makarychev V A, Kosharskaia I L, Ul'ianinskiĭ L S
Biull Eksp Biol Med. 1976 May;81(5):517-20.
The microelectrode technique applied revealed an automatic activity of the pacemaker cells with slow diastolic depolarization in the cusps of the atrioventricular valves obtained from 34 rabbit hearts. Electrophysiological characteristics of the action potentials of these cells were investigated. Inhibitors of slow sodium-calcium canal (Mn++, Co++, and Mg++ ions) proved to eliminate the automatic activity of the pacemaker cells. When the content of potassium ions was elevated in the perfusion solution, no suppression occurred. It is suggested that the automatic activity of the pacemaker cells in the atrioventricular values depended mainly on the functioning of the slow sodium-calcium canal.
应用微电极技术显示，从34只兔心脏获取的房室瓣尖部的起搏细胞具有舒张期缓慢去极化的自动活动。对这些细胞动作电位的电生理特性进行了研究。结果证明，慢钠钙通道抑制剂（锰离子、钴离子和镁离子）可消除起搏细胞的自动活动。当灌注液中钾离子含量升高时，未出现抑制现象。提示房室瓣中起搏细胞的自动活动主要依赖于慢钠钙通道的功能。
