Matveev P V, Tsys' O N, Kogan A S
Biull Eksp Biol Med. 1976 May;81(5):520-2.
The authors studied changes in the general hemodynamics in healthy nonanesthetized dogs in infusion of 27/ng/kg/min of angiotensin II into the superior vena cava and the portal vein. Portal infusion of the peptide produced a less pronounced pressor effect. Elevation of arterial pressure in systemic infusion of angiotension occurred on account of increase in the peripheral vascular resistance with decrease of minute circulation volume. In portal infusion of the preparation elevation of arterial pressure was mainly due to increase of the minute circulation volume. Differences in hemodynamic reactions could not be attributed only to the peptide metabolization in the liver. It is possible that depressor agents entered the blood from the liver in portal angiotensin II infusion.
作者研究了在健康未麻醉犬的上腔静脉和门静脉中输注27 ng/kg/min血管紧张素II时其全身血流动力学的变化。门静脉输注该肽产生的升压作用不太明显。全身输注血管紧张素时动脉压升高是由于外周血管阻力增加以及分钟循环血量减少所致。在门静脉输注该制剂时，动脉压升高主要是由于分钟循环血量增加。血流动力学反应的差异不能仅仅归因于肝脏中该肽的代谢。在门静脉输注血管紧张素II时，可能有降压物质从肝脏进入血液。
