Tsuru H, Ishikawa N, Shigei T
Blood Vessels. 1976;13(4):238-48. doi: 10.1159/000158092.
Contractile responses of isolated dog veins to bradykinin were studied. Responses to norepinephrine were taken as standards. According to their sensitivity to bradykinin, the veins obtained from 14 sites of the venous system were divided into two groups, while all the veins were almost uniform in their sensitivity to norepinephrine. One group has high sensitivity to bradykinin and the other has low sensitivity. The former includes the pulmonary, hepatic, splenic, and portal veins, the anterior vena cava, and the upper and the middle divisions of the posterior vena cava. The latter includes the external jugular, cephalic, azygos, femoral, and saphenous veins, and the lower division of the posterior vena cava. The responses of the renal vein were intermediate. A striking correlation was noted between the distribution of bradykinin sensitivity and the genesis of the venous system. Five bioactive peptides other than bradykinin were also studied. Only angiotensin induced contraction in some preparation, but, as a whole, caerulein, eledoisin-related peptide, oxytocin and vasopressin rarely showed contractile activity.
研究了离体犬静脉对缓激肽的收缩反应。以对去甲肾上腺素的反应作为标准。根据对缓激肽的敏感性，将取自静脉系统14个部位的静脉分为两组，而所有静脉对去甲肾上腺素的敏感性几乎一致。一组对缓激肽敏感，另一组对缓激肽不敏感。前者包括肺静脉、肝静脉、脾静脉、门静脉、前腔静脉以及后腔静脉的上、中部分。后者包括颈外静脉、头静脉、奇静脉、股静脉、大隐静脉以及后腔静脉的下部分。肾静脉的反应介于两者之间。观察到缓激肽敏感性的分布与静脉系统的发生之间存在显著相关性。还研究了除缓激肽以外的5种生物活性肽。只有血管紧张素在某些制剂中引起收缩，但总体而言，蛙皮素、伊索肽、催产素和加压素很少表现出收缩活性。
