Howarth P H
Southampton General Hospital, U.K.
Respir Med. 1997 Nov;91 Suppl A:2-8. doi: 10.1016/s0954-6111(97)90096-2.
The characterisation of chronic asthma as an inflammatory condition of the human airway, associated with heightened airway responsiveness to a variety of bronchial stimuli, has lead to the clarification of therapeutic strategies. These strategies have focused on bronchodilation and attenuation of airway inflammation. Inhaled corticosteroids effectively reduce chronic inflammation and produce substantial symptomatic relief in most patients. This article examines the pathophysiology of asthma and discusses the interpretation of current methods of assessment, and the targets and actions of inhaled anti-asthmatic drugs in relationship to central and peripheral airway events.
将慢性哮喘描述为一种人类气道的炎症性疾病，伴有气道对多种支气管刺激的反应性增强，这使得治疗策略得以明确。这些策略主要集中在支气管扩张和减轻气道炎症方面。吸入性糖皮质激素能有效减轻慢性炎症，并使大多数患者的症状得到显著缓解。本文探讨了哮喘的病理生理学，讨论了当前评估方法的解读，以及吸入性抗哮喘药物相对于中央和外周气道事件的作用靶点和作用机制。
