Messin R, Karpov Y, Baikova N, Bruhwyler J, Monseu M J, Guns C, Géczy J
Department of Cardiology, University Hospital Saint Pierre, Brussels, Belgium.
J Cardiovasc Pharmacol. 1998 Feb;31(2):271-6. doi: 10.1097/00005344-199802000-00013.
A multicenter, randomized, double-blind, crossover, placebo-controlled study was conducted in 90 isosorbide dinitrate responders showing stable angina to compare the efficacy of molsidomine retard, 8 mg b.i.d., with that of molsidomine, 4 mg t.i.d., for 6 weeks. Total work performance (workload x min) was significantly improved, compared with baseline and placebo until 8 and 12 h after molsidomine and molsidomine retard administration, respectively. ST-segment depression decreased significantly under the two treatments at 60 W as well as at maximal exercise. The rate-pressure product (heart rate x systolic blood pressure) decreased and increased significantly at submaximal and maximal exercise level, respectively. All these effects remained significant after 6-week treatment, with only the ST segment showing a nonsignificant tendency to improvement at maximal work. The frequency of anginal attacks and of sublingual nitroderivative-tablets consumption decreased significantly with molsidomine, 4 mg, and molsidomine retard, 8 mg. However, overall results showed that the latter form reduces myocardial ischemia more efficiently at submaximal exercise level, has a more prolonged effect on exercise tolerance, and maintains it at a somewhat higher level after 6-week treatment.
对90名服用硝酸异山梨酯后出现稳定型心绞痛的患者进行了一项多中心、随机、双盲、交叉、安慰剂对照研究，以比较每日两次服用8毫克缓释吗多明与每日三次服用4毫克吗多明的疗效，为期6周。与基线和安慰剂相比，分别在服用吗多明和缓释吗多明后8小时和12小时，总工作表现（工作量×分钟）显著改善。在60瓦以及最大运动量时，两种治疗下ST段压低均显著降低。在次最大运动量和最大运动量水平时，心率-血压乘积（心率×收缩压）分别显著降低和升高。经过6周治疗后，所有这些效应仍然显著，只有ST段在最大工作量时改善趋势不显著。服用4毫克吗多明和8毫克缓释吗多明后，心绞痛发作频率和舌下含服硝酸酯类药物的次数显著减少。然而，总体结果显示，后一种剂型在次最大运动量水平时能更有效地减轻心肌缺血，对运动耐量的影响持续时间更长，且在6周治疗后能将运动耐量维持在稍高的水平。
