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大米与葡萄糖口服补液溶液用于婴幼儿急性水样腹泻的随机对照临床试验

Randomized, controlled, clinical trial of rice versus glucose oral rehydration solutions in infants and young children with acute watery diarrhoea.

作者信息

Faruque A S, Hoque S S, Fuchs G J, Mahalanabis D

机构信息

International Centre for Diarrhoeal Disease Research, Bangladesh, Dhaka.

出版信息

Acta Paediatr. 1997 Dec;86(12):1308-11. doi: 10.1111/j.1651-2227.1997.tb14903.x.

Abstract

A randomized clinical trial was carried out to compare a packaged ready-to-mix rice oral rehydration solution (ORS) to the standard glucose ORS for the treatment of childhood diarrhoea. Children were of either gender, aged 3-35 months, presenting with a history of watery diarrhoea for 72 h or less. The main outcomes examined were stool output, ORS intake, duration of diarrhoea and nutritional recovery during follow-up at 16 d of illness. Stool output in the first 24 h (106 vs 107 g kg(-1)), ORS intake in clinic (93 vs 102 ml per motion) and duration of diarrhoea (88 h vs 81 h) were similar in the two treatment groups. The few episodes that became persistent were similar (2%) in the two groups. The weight gain during follow-up was similar in the two ORS groups.

摘要

开展了一项随机临床试验,以比较预混包装大米口服补液盐(ORS)与标准葡萄糖ORS治疗儿童腹泻的效果。研究对象为3至35个月的儿童,无论性别,出现水样腹泻病史72小时及以内。主要观察指标包括粪便排出量、ORS摄入量、腹泻持续时间以及发病16天时随访期间的营养恢复情况。两个治疗组在前24小时的粪便排出量(106 vs 107 g·kg⁻¹)、门诊ORS摄入量(每次排便93 vs 102 ml)和腹泻持续时间(88小时 vs 81小时)相似。两组中转为持续性腹泻的病例数相近(均为2%)。两个ORS组在随访期间的体重增加情况相似。

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