Sucić M, Bozikov V, Mesić R, Sokolić L
Department of Medicine, Dubrava University Hospital, Avenija izvidaca 6, Zagreb, 10000, Croatia.
Croat Med J. 1998 Mar;39(1):19-22.
To investigate the possible effects of thyroid hormones on the lipoprotein (a) (Lp(a)) serum concentration.
Eleven patients with hyperthyroidism (Grave's disease), 18 patients with hypothyroidism and low Lp(a) (Hashimoto's disease), and 13 patients with hypothyroidism (Hashimoto's disease) and elevated Lp(a) were examined before and after thyroid hormone normalization. The measurements included total cholesterol, HDL cholesterol (including HDL2 and HDL3 subfractions), LDL cholesterol, VLDL cholesterol, triglycerides, apoproteins A1 and B, and Lp(a), thyrotropin (TSH) and thyroid hormones/total thyroxine (T4), triiodothyronine (T3), free thyroxine (FT4), and free triiodothyronine (FT3).
In patients with hyperthyroidism, serum concentrations of total cholesterol, LDL cholesterol, and apo B significantly increased (p<0.05) after the treatment, whereas a moderate increase in HDL (HDL2 subfraction), triglyceride, and Lp(a) concentrations did not reach statistical significance. In both groups of patients with hypothyroidism, concentrations of total cholesterol, LDL cholesterol, apo B, and triglycerides significantly decreased after the treatment, whereas the changes in HDL (HDL2 and HDL3 subfractions), VLDL cholesterol, apo A1, and Lp(a) were not significant.
Thyroid hormones had only a moderate effect on the metabolism of Lp(a).
研究甲状腺激素对血清脂蛋白(a) [Lp(a)]浓度可能产生的影响。
对11例甲状腺功能亢进症（格雷夫斯病）患者、18例甲状腺功能减退且Lp(a)水平低的患者（桥本氏病）以及13例甲状腺功能减退且Lp(a)水平升高的患者（桥本氏病）在甲状腺激素恢复正常前后进行检查。测量项目包括总胆固醇、高密度脂蛋白胆固醇（包括HDL2和HDL3亚组分）、低密度脂蛋白胆固醇、极低密度脂蛋白胆固醇、甘油三酯、载脂蛋白A1和B以及Lp(a)、促甲状腺激素（TSH）和甲状腺激素/总甲状腺素（T4）、三碘甲状腺原氨酸（T3）、游离甲状腺素（FT4）和游离三碘甲状腺原氨酸（FT3）。
甲状腺功能亢进症患者治疗后，血清总胆固醇、低密度脂蛋白胆固醇和载脂蛋白B浓度显著升高（p<0.05），而高密度脂蛋白（HDL2亚组分）、甘油三酯和Lp(a)浓度的适度升高未达到统计学显著性。两组甲状腺功能减退症患者治疗后，总胆固醇、低密度脂蛋白胆固醇、载脂蛋白B和甘油三酯浓度均显著降低，而高密度脂蛋白（HDL2和HDL3亚组分）、极低密度脂蛋白胆固醇、载脂蛋白A1和Lp(a)的变化不显著。
甲状腺激素对Lp(a)的代谢仅有适度影响。
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