Gomo Z, Ascott M B
Department of Chemical Pathology, University of Zimbabwe Medical School, Avondale, Harare.
Cent Afr J Med. 1994 Apr;40(4):94-8.
Serum levels of thyroid stimulating hormones (TSH), cholesterol, triglycerides, lipoproteins and high density lipoprotein subfractions were determined in 80 patients and 150 age and sex matched controls. The lipids and lipoproteins distribution showed a significant increase in total cholesterol and LDL-C levels in the patient group (p < 0.001). In contrast the HDL-C and its subfractions (HDL2-C and HDL3-C) were significantly lower in the patient groups (p < 0.001). The ratio of HDL-C:total cholesterol was significantly higher in the control group (p < 0.001). This is suggestive of low HDL-C in hypothyroid patients and a high HDL-C in the control group. The relationship of TSH and lipids or lipoproteins indicates a positive association. These results suggest that thyroid dysfunction exerts atherogenic effects through the metabolism of cholesterol. Furthermore, the study indicates that the ratios of HDL and its subfractions of total cholesterol and LDL provide additional parameters for the assessment of the risk of developing coronary heart disease.
对80例患者及150名年龄和性别匹配的对照者测定了血清促甲状腺激素（TSH）、胆固醇、甘油三酯、脂蛋白及高密度脂蛋白亚组分水平。脂质和脂蛋白分布显示，患者组总胆固醇和低密度脂蛋白胆固醇（LDL-C）水平显著升高（p<0.001）。相比之下，患者组高密度脂蛋白胆固醇（HDL-C）及其亚组分（HDL2-C和HDL3-C）显著降低（p<0.001）。对照组HDL-C与总胆固醇的比值显著更高（p<0.001）。这提示甲状腺功能减退患者HDL-C水平较低，而对照组HDL-C水平较高。TSH与脂质或脂蛋白的关系表明存在正相关。这些结果提示，甲状腺功能障碍通过胆固醇代谢发挥致动脉粥样硬化作用。此外，该研究表明，HDL及其亚组分与总胆固醇和LDL的比值为评估冠心病发生风险提供了额外参数。
