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老年人冠心病与抑郁症——一项基于人群的研究。

Coronary heart disease and depression in the elderly--a population-based study.

作者信息

Ahto M, Isoaho R, Puolijoki H, Laippala P, Romo M, Kivelä S L

机构信息

Unit of General Practice, Oulu University Hospital, Finland.

出版信息

Fam Pract. 1997 Dec;14(6):436-45. doi: 10.1093/oxfordjournals.fampra.a018286.

Abstract

BACKGROUND

Growing interest is nowadays focused on the quality of life of elderly people who survive with chronic diseases. Coronary heart disease (CHD) is one of the most common diseases among the elderly and may have an unfavourable impact on the patient's emotional well-being.

OBJECTIVES

We aimed to describe the prevalence of depression and the occurrence of depressive symptoms among elderly CHD patients, with a special emphasis on the relations between depression and the severity of CHD, and to find out the possible association between CHD and depression.

METHODS

The study was carried out at the health centre of the municipality of Lieto, in south-west Finland. The study population consisted of 488 community-dwelling men and 708 women, over 64 years old, from among whom the participants with CHD (89 men and 73 women) were selected, and for whom 178 male and 146 female sex- and age-matched controls (free of CHD) were drawn from the population. CHD patients were selected on the basis of the presence of angina pectoris or a past myocardial infarction. Depressive symptoms were measured with the Zung Self-rating Depression Scale. Depression was described in relation to the severity of dyspnoea and chest pain among patients. The associations between depression and age, health, health behaviour, drugs, functional ability and social, psychosocial and environmental factors were analysed by logistic regression analyses.

RESULTS

The prevalence of depression was 29% among male patients and 20% among female patients. Depression was significantly more common among male CHD patients than among male controls (P = 0.011). Among women, depression was not associated with CHD. Earlier, depression had gone undiagnosed among many CHD patients and controls, especially male patients. Among male CHD patients, depression was associated with more severe dyspnoea, but no similar association was found among female CHD patients. Among men the occurrence of CHD, physical disability, widowhood or divorce, and among women previous clinical depression, physical disability and the use of angiotensin-converting enzyme (ACE) inhibitors, were associated with depression.

CONCLUSION

Depression is common among patients with CHD. It seems that CHD is not an independent factor in the aetiology of depression among the elderly. The association of CHD with depression among men is explained by the acute or chronic psychic stress caused by CHD. It may be that the more complicated the patient's CHD, the more probable is the presence of depression.

摘要

背景

如今,人们越来越关注患有慢性病的老年人的生活质量。冠心病(CHD)是老年人中最常见的疾病之一,可能会对患者的情绪健康产生不利影响。

目的

我们旨在描述老年冠心病患者中抑郁症的患病率和抑郁症状的发生情况,特别强调抑郁症与冠心病严重程度之间的关系,并找出冠心病与抑郁症之间可能的关联。

方法

该研究在芬兰西南部列托市的健康中心进行。研究人群包括488名社区居住的男性和708名女性,年龄均超过64岁,从中选取了患有冠心病的参与者(89名男性和73名女性),并从该人群中抽取了178名年龄和性别匹配的男性和146名年龄和性别匹配的女性作为对照(无冠心病)。冠心病患者是根据是否存在心绞痛或既往心肌梗死来选取的。使用zung自评抑郁量表测量抑郁症状。根据患者呼吸困难和胸痛的严重程度描述抑郁症情况。通过逻辑回归分析分析抑郁症与年龄、健康状况、健康行为、药物、功能能力以及社会、心理社会和环境因素之间的关联。

结果

男性患者中抑郁症的患病率为29%,女性患者中为20%。男性冠心病患者中抑郁症明显比男性对照更常见(P = 0.011)。在女性中,抑郁症与冠心病无关。此前,许多冠心病患者和对照,尤其是男性患者,抑郁症未被诊断出来。在男性冠心病患者中,抑郁症与更严重的呼吸困难有关,但在女性冠心病患者中未发现类似关联。在男性中,冠心病的发生、身体残疾、丧偶或离婚,在女性中,既往临床抑郁症、身体残疾和使用血管紧张素转换酶(ACE)抑制剂,与抑郁症有关。

结论

抑郁症在冠心病患者中很常见。冠心病似乎不是老年人抑郁症病因中的独立因素。男性中冠心病与抑郁症的关联是由冠心病引起的急性或慢性心理压力所解释的。可能患者的冠心病越复杂,患抑郁症的可能性就越大。

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