天然及超声处理的双链多聚核糖核苷酸对NZB和NZB/瑞士F1小鼠自发性自身免疫疾病病程的影响。
The effect of native and sonicated double-stranded polyribonucleotides on the course of spontaneous autoimmune disease in NZB and NZB/Swiss F1 mice.
作者信息
Pekárek J, Rovenský J, Doskocil J, Rossmann P, Korcáková L, Rovenská E, Lackovic V, Borecký L, Svejcar J, Mistina T, Zitnan D
出版信息
Acta Virol. 1979 Nov;23(6):481-8.
PMID:94768
Abstract
The administration of sonicated fractions of f2 phage polyribonucleotides caused an increased weight loss and deterioration of the clinical state in female NZB mice. Discontinuance of the treatment resulted in an improvement of both the clinical state and the genetically determined autoimmune disorders of these mice. Some potential explanations of this effect are discussed.
摘要
给雌性新西兰黑鼠（NZB）注射经超声处理的f2噬菌体多聚核糖核苷酸片段，会导致其体重下降加剧，临床状态恶化。停止治疗后，这些小鼠的临床状态以及由基因决定的自身免疫性疾病均有所改善。本文讨论了对此效应的一些可能解释。
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