Robledo M M, Teixidó J
Centro de Investigaciones Biológicas, Departamento de Immunología Velásquez, Madrid, Spain.
Leuk Lymphoma. 1997 Nov;27(5-6):509-15. doi: 10.3109/10428199709058318.
The stromal cells are integral components of the bone marrow (BM) that provide and respond to cytokines, and offer adhesion elements for hematopoietic cell homing. Steady-state hematopoiesis results from a balance between negative and positive acting cytokines, whose expression is in addition the subject of regulation. TGF-beta1 is present in the BM microenvironment and plays a central role in controlling hematopoiesis, by modulating the synthesis of cytokines and cytokine receptors, as well as cell adhesion molecules. We have recently described the TGF-beta1 receptor system expressed on human BM stromal cells. The consequences of signalling through this system, which can affect stromal cell function, and hence, influence the hematopoiesis, is the subject of this review.
基质细胞是骨髓（BM）的重要组成部分，它们提供细胞因子并对其作出反应，为造血细胞归巢提供黏附因子。稳态造血是正负作用细胞因子之间平衡的结果，这些细胞因子的表达还受到调控。转化生长因子-β1（TGF-β1）存在于骨髓微环境中，通过调节细胞因子、细胞因子受体以及细胞黏附分子的合成，在控制造血过程中发挥核心作用。我们最近描述了人类骨髓基质细胞上表达的TGF-β1受体系统。通过该系统进行信号传导的后果，会影响基质细胞功能，进而影响造血，这是本综述的主题。
