Müller R A, Chugani H T, Muzik O, Mangner T J
Department of Pediatrics, Children's Hospital of Michigan, Wayne State University, Detroit 48201-2196, USA.
J Child Neurol. 1998 Jan;13(1):16-22. doi: 10.1177/088307389801300103.
The capacity of the developing brain for compensatory reorganization after early hemispherectomy has been previously shown in neurobehavioral studies, above all with regard to language recovery. The present study examines the organization of motor and language areas by means of [(15)O]-water positron emission tomography (PET) in a 6-year-old boy who underwent right functional hemispherectomy at age 3 years. The results suggest that compensatory allocation for movement of the weak hand primarily involves the premotor, inferior frontal, and insular cortices, and the supplementary motor area in the retained hemisphere, as well as the bilateral cerebellum. Receptive language and prosodic functions primarily activated the left perisylvian cortices. However, language and motor activations were also seen in cortical and subcortical remains on the hemispherectomized side suggesting incomplete disconnection by functional hemispherectomy.
早期大脑半球切除术后发育中的大脑进行代偿性重组的能力先前已在神经行为研究中得到证实，尤其是在语言恢复方面。本研究通过[（15）O] - 水正电子发射断层扫描（PET）检查了一名6岁男孩的运动和语言区域组织，该男孩在3岁时接受了右侧功能性大脑半球切除术。结果表明，对弱侧手运动的代偿性分配主要涉及运动前区、额下回和岛叶皮质，以及保留半球中的辅助运动区，还有双侧小脑。接受性语言和韵律功能主要激活了左侧颞叶周围皮质。然而，在大脑半球切除侧的皮质和皮质下残余部分也观察到了语言和运动激活，这表明功能性大脑半球切除术并未完全切断联系。
