Koo W W, Bush A J, Walters J, Carlson S E
Department of Pediatrics, University of Tennessee, Memphis, USA.
J Am Coll Nutr. 1998 Feb;17(1):65-70. doi: 10.1080/07315724.1998.10720457.
To determine postnatal development in bone mineral status and its relationship to anthropometric measurements and other physiologic variables during the first year.
Cross-section observational study of total body bone mineral content (TB BMC) and density (TB BMD) of 130 healthy infants (71 male and 59 female with 63 white and 67 African American) between 1 and 391 days. Whole body dual energy X ray absorptiometry (DXA) scans were performed on unsedated infants using a bone densitometer with pediatric platform. Scan analyses were performed with software version V5.64P. The ability of study independent variables to explain variance in bone mineral status was determined by multiple linear regression analysis.
During infancy, average TB BMC increased by 389% and TB BMD increased by 157%. The best determinant of bone mineral status is body weight which accounted for 97% of TB BMC, 98% of TB area and 86% of TB BMD variation. Postnatal age and body length jointly added only 1%, < 1% and 2.5%, respectively, to the explained variation of these DXA measurements; race, gender and season all failed to reach statistical significance.
In healthy infants, body weight is the dominant predictor of bone mineral status. The percent increase in TB BMC differs from increase in TB BMD. Normative data generated from this study would be useful in the identification of abnormal bone mineral status in infants.
确定出生后第一年骨矿物质状态的发育情况及其与人体测量指标和其他生理变量的关系。
对130名1至391日龄的健康婴儿（71名男性和59名女性，其中63名白人、67名非裔美国人）的全身骨矿物质含量（TB BMC）和骨密度（TB BMD）进行横断面观察研究。使用带有儿科平台的骨密度仪对未使用镇静剂的婴儿进行全身双能X线吸收法（DXA）扫描。使用V5.64P软件版本进行扫描分析。通过多元线性回归分析确定研究自变量解释骨矿物质状态差异的能力。
在婴儿期，平均TB BMC增加了389%，TB BMD增加了157%。骨矿物质状态的最佳决定因素是体重，其分别占TB BMC变化的97%、TB面积变化的98%和TB BMD变化的86%。出生后年龄和身长分别仅使这些DXA测量值的解释变异增加了1%、<1%和2.5%；种族、性别和季节均未达到统计学显著性。
在健康婴儿中，体重是骨矿物质状态的主要预测因素。TB BMC的增加百分比与TB BMD的增加不同。本研究生成的标准数据将有助于识别婴儿的异常骨矿物质状态。
