Raffn E, Villadsen E, Engholm G, Lynge E
Kraeftens Bekaempelse, København.
Ugeskr Laeger. 1998 Feb 9;160(7):1029-33.
A cohort of 7887 men and 576 women employed between 1928 and 1984 at a Danish asbestos cement factory Dansk Eternit Fabrik A/S was followed up for deaths, immigrations, and incident cancer cases during 1943-90. The observed number of lung cancer cases was compared with the expected number based on incidence rates for the Danish population. Internal comparison was made with Poisson modelling. A total of 226 lung cancer cases was observed; 223 cases among men and three among women. The standardised incidence ratio (SIR) for all lung cancer cases for men was 1.7; for adenocarcinoma 2.6, squamous cell carcinoma 1.7, and anaplastic carcinoma 1.5. Among the 93 excess lung cancer cases, 36 were squamous cell carcinomas, 32 adenocarcinomas and 17 anaplastic carcinomas. During the first 25 years after the start of employment the excess risk was shared almost equally between the different histological types of lung cancer, but the risk of adenocarcinomas was clearly higher after this point.
对1928年至1984年间受雇于丹麦石棉水泥工厂丹斯克永恒工厂有限公司(Dansk Eternit Fabrik A/S)的7887名男性和576名女性进行了队列研究,随访其在1943年至1990年期间的死亡、移民和新发癌症病例情况。将观察到的肺癌病例数与基于丹麦人群发病率的预期病例数进行比较。采用泊松模型进行内部比较。共观察到226例肺癌病例;男性223例,女性3例。男性所有肺癌病例的标准化发病比(SIR)为1.7;腺癌为2.6,鳞状细胞癌为1.7,间变性癌为1.5。在93例超额肺癌病例中,36例为鳞状细胞癌,32例为腺癌,17例为间变性癌。在开始工作后的前25年中,不同组织学类型的肺癌超额风险几乎均等,但此后腺癌的风险明显更高。