Magnani C, Zanetti R, Schiavo D, Leporati M, Botta M
Servizio Universitario di Epidemiologia dei Tumori, Azienda Ospedaliera S. Giovanni Battista, Torino.
Epidemiol Prev. 1995 Dec;19(65):338-41.
The study presents mortality rates for lung cancer in the town of Casale Monferrato, where the largest Italian asbestos cement-plant was located. Cases of lung cancer dying in 1989-94 were exhaustively searched for in the register of deaths. Each case of lung cancer has been identified as ever or never employed in the factory with a linkage to the rosters of employees in the plant. Women were also identified as ever or never married to an asbestos-cement worker. The number of person-years at risk for asbestos cement workers and their wives was measured on the basis of the most recent follow-up. Mortality rates were computed separately for those exposed (workers and wives of workers) and for those with no evidence of exposure. Mortality rates for non-exposed were similar to rates in Piedmont (the region where Casale is located). The relative risk (ever exposed vs. never exposed) was 2.8 among men and 2.1 among women. Attributable risk among the exposed was 64.5% for men and 53.1% for women while among the general population it was 18.1% for men and 13.2% for women. The study confirms the dramatic effect of occupational asbestos exposure in Casale Monferrato but does not suggest an increase in lung cancer mortality among people with no occupational activity in the asbestos-cement production.
该研究呈现了卡萨莱蒙费拉托镇的肺癌死亡率，这里曾坐落着意大利最大的石棉水泥厂。在死亡登记册中详尽搜索了1989年至1994年期间死于肺癌的病例。每一例肺癌患者都被确定是否曾在该工厂工作，这通过与工厂员工名册进行关联来确定。女性也被确定是否曾与石棉水泥工人结婚。根据最新的随访情况来计算石棉水泥工人及其妻子的暴露人年数。分别计算了暴露人群（工人及其妻子）和无暴露证据人群的死亡率。未暴露人群的死亡率与皮埃蒙特地区（卡萨莱所在地区）的死亡率相似。男性的相对风险（曾暴露与未暴露相比）为2.8，女性为2.1。暴露人群中男性的归因风险为64.5%，女性为53.1%；而在普通人群中，男性为18.1%，女性为13.2%。该研究证实了在卡萨莱蒙费拉托职业性接触石棉的巨大影响，但并未表明在石棉水泥生产中无职业活动的人群肺癌死亡率有所增加。
