Wisborg K, Henriksen T B, Hedegaard M, Secher N J
Arhus Universitetshospital, Skejby Sygehus, gynaekologisk obstetrisk afdeling Y.
Ugeskr Laeger. 1998 Feb 9;160(7):1033-7.
The purpose of the study was to evaluate the association between smoking during pregnancy and preterm birth. The overall rate of preterm delivery was 4.3%. Smokers had a 40% higher risk of preterm birth compared to non-smokers. A dose response relationship was found between smoking and risk of preterm birth. Adjustment for women's height, pre-pregnant weight, age of the mother, marital status, education, occupational status, and alcohol intake did not change the results. Among women with an intake of less than 400 mg of caffeine per day no difference in the risk of preterm birth between smokers and non-smokers was found. However, among women with an intake of more than 400 mg of caffeine per day, the risk of preterm birth was increased almost threefold among smokers compared to non-smokers. Furthermore, among women with a high intake of caffeine a dose response relationship was found between smoking and risk of preterm delivery.
该研究的目的是评估孕期吸烟与早产之间的关联。早产的总体发生率为4.3%。与不吸烟者相比，吸烟者早产的风险高40%。发现吸烟与早产风险之间存在剂量反应关系。对女性的身高、孕前体重、母亲年龄、婚姻状况、教育程度、职业状况和酒精摄入量进行调整后，结果没有改变。在每天咖啡因摄入量低于400毫克的女性中，未发现吸烟者和不吸烟者之间早产风险存在差异。然而，在每天咖啡因摄入量超过400毫克的女性中，与不吸烟者相比，吸烟者早产的风险几乎增加了两倍。此外，在咖啡因摄入量高的女性中，发现吸烟与早产风险之间存在剂量反应关系。
