Matalliotakis I, Panidis D, Vlassis G, Neonaki M, Koumantakis E
Third Department of Obstetrics and Gynecology, Aristotelion University of Thessaloniki, Greece.
Clin Exp Obstet Gynecol. 1997;24(3):160-2.
The aim of this study was to verify to what extent danazol alters insulin sensitivity. To this end, insulin tests were performed before the application of danazol and during the last 15 days of a six-month treatment with this agent on nine women, from 21 to 37 years of age, who had endometriosis. The same test was also performed on nine healthy women, 21 to 35 years of age, in whom laparoscopy did not reveal endometriosis or other pelvic pathology. It was found that the total response of glucose to insulin was significantly lower in women with endometriosis during treatment with danazol than it was in the same women before the application of this agent or in normal women too. Our results support the view that danazol induces resistance to insulin.
本研究的目的是验证达那唑在多大程度上改变胰岛素敏感性。为此，对9名年龄在21至37岁患有子宫内膜异位症的女性，在使用达那唑之前以及使用该药物进行为期6个月治疗的最后15天期间进行了胰岛素测试。对9名年龄在21至35岁的健康女性也进行了同样的测试，这些女性经腹腔镜检查未发现子宫内膜异位症或其他盆腔病变。结果发现，子宫内膜异位症女性在使用达那唑治疗期间，葡萄糖对胰岛素的总体反应显著低于使用该药物之前的同一批女性，也低于正常女性。我们的结果支持达那唑会诱导胰岛素抵抗这一观点。
