Schmidt K G, von Rückmann A, Mittag T W
Department of Ophthalmology, Mt. Sinai School of Medicine, New York, NY, USA.
Ophthalmologica. 1998;212(1):5-10. doi: 10.1159/000027250.
The present study was designed to investigate choroidal perfusion in primary open-angle glaucoma patients with statistically elevated (HPG) and statistically normal (NPG) intraocular pressure (IOP) and in ocular hypertensive volunteers (OHT) before and after application of topical antiglaucomatous drugs. When compared to age-matched healthy controls, ocular pulse amplitude (OPA) and IOP were significantly increased in OHT and unchanged in HPG; in NPG, the IOP was unchanged, and the OPA was significantly reduced. The topical antiglaucomatous drugs used in this study reduced IOP, but did not increase OPA. When compared to HPG and NPG, OHT subjects showed increased choroidal perfusion which may help to prevent glaucomatous optic nerve damage.
本研究旨在调查原发性开角型青光眼患者中眼压统计学升高(HPG)和眼压统计学正常(NPG)者以及高眼压志愿者(OHT)在局部应用抗青光眼药物前后的脉络膜灌注情况。与年龄匹配的健康对照组相比,OHT的眼脉搏振幅(OPA)和眼压显著升高,HPG组则无变化;NPG组眼压无变化,OPA显著降低。本研究中使用的局部抗青光眼药物降低了眼压,但未增加OPA。与HPG和NPG相比,OHT受试者的脉络膜灌注增加,这可能有助于预防青光眼性视神经损伤。