Gralewicz S, Walusiak-Stankiewicz J
Zakładu Oceny Toksyczności, Instytutu Medycyny Pracy w Lodzi.
Przegl Lek. 1997;54(7-8):565-7.
Epileptogenic properties of penicillin, applied either directly to the brain or systemically, have been known for many years and may be also of clinical importance. In the present work different aspects of this action, including clinical ones, as well as risk factors for the occurrence of epileptic seizures, and mechanism of penicillin action in the central nervous system have been shortly described. Moreover, results of experimental studies confirming epileptogenic properties of many antibiotics, mainly b-lactams, have been mentioned. Data from experimental studies, revealing the possibility of long-term adverse effects of repeated injections of convulsants, have been emphasized, and the absence of relevant clinical studies has been pointed out. Widespread usage of beta-lactam antibiotics should encourage medical personnel to pay more attention to all these problems in everyday clinical practice.
青霉素无论是直接应用于大脑还是全身应用，其致癫痫特性已为人所知多年，并且可能也具有临床重要性。在本研究中，简要描述了该作用的不同方面，包括临床方面、癫痫发作发生的危险因素以及青霉素在中枢神经系统中的作用机制。此外，还提及了证实许多抗生素（主要是β-内酰胺类）具有致癫痫特性的实验研究结果。强调了实验研究数据揭示的反复注射惊厥剂可能产生长期不良影响，同时指出缺乏相关的临床研究。β-内酰胺类抗生素的广泛使用应促使医务人员在日常临床实践中更加关注所有这些问题。
