Huynh Do P, Joris F
Institut Central des Hôpitaux Valaisans, Sion.
Praxis (Bern 1994). 1997 Nov 19;86(47):1854-9.
Malignant melanoma (MM) is a skin neoplasm with an increasing incidence. Late discovery is often associated with lethal outcome. Among the possible precursor lesions of MM, the Dysplastic Naevus (DN) is a matter of controversy. We have studied 4 cases of Dysplastic Naevus Syndrome (DNS) and analysed 39 lesions of Dysplastic Naevus. We adopt the "ABCDE" rule (A = Asymmetry, B = Border irregularity, C = Colour inhomogeneity, D = Diameter > 0.5 cm, E = Elevation or Extension) for clinical diagnosis of DN or MM. We conclude that the DN is a risk marker, a precursor of MM and a potential precancerosis. We present recommendations for management of the Dysplastic Naevus Syndrome and prevention of malignant melanoma.
恶性黑色素瘤（MM）是一种发病率不断上升的皮肤肿瘤。发现较晚往往与致命后果相关。在MM可能的前驱病变中，发育异常痣（DN）存在争议。我们研究了4例发育异常痣综合征（DNS），并分析了39个发育异常痣病变。我们采用“ABCDE”规则（A = 不对称，B = 边界不规则，C = 颜色不均匀，D = 直径>0.5 cm，E = 隆起或扩展）对DN或MM进行临床诊断。我们得出结论，DN是一个风险标志物，是MM的前驱病变，也是一种潜在的癌前病变。我们提出了发育异常痣综合征的管理和恶性黑色素瘤预防的建议。
