Yamanobe S, Nakagawa Y, Hishinuma T, Mizugaki M, Tamai M
Department of Ophthalmology, Tohoku University School of Medicine, Sendai, Japan.
Prostaglandins Leukot Essent Fatty Acids. 1998 Jan;58(1):65-8. doi: 10.1016/s0952-3278(98)90131-4.
We describe variations of 11-dehydrothromboxane B2(11-dehydro-TXB2) levels in human urine samples. Retinal vein occlusion (RVO) is a thrombotic disease in which the retinal vein is blocked by blood aggregations. We considered the possibility that 11-dehydro-TXB2 plays an important role in the formation of RVO. Thus, we determined the 11-dehydro-TXB2 levels in patients with RVO using gas chromatography/selected ion monitoring (GC/SIM) and compared them with those of healthy volunteers. The thromboxane levels in patients with RVO, who did not also have diabetes, were significantly higher than those in healthy volunteers. One cause of RVO may be the variation of thromboxane production. Furthermore, this GC/SIM method can be applied to the prevention and treatment of not only RVO, but also of general thrombosis.
我们描述了人类尿液样本中11-脱氢血栓素B2（11-dehydro-TXB2）水平的变化情况。视网膜静脉阻塞（RVO）是一种血栓形成性疾病，其中视网膜静脉被血液凝块阻塞。我们考虑了11-脱氢-TXB2在RVO形成中起重要作用的可能性。因此，我们使用气相色谱/选择离子监测（GC/SIM）测定了RVO患者的11-脱氢-TXB2水平，并将其与健康志愿者的水平进行了比较。未患糖尿病的RVO患者的血栓素水平显著高于健康志愿者。RVO的一个原因可能是血栓素产生的变化。此外，这种GC/SIM方法不仅可应用于RVO的预防和治疗，也可应用于一般血栓形成的预防和治疗。
