Sofair A F, Zohman L R, Thomas M A
Department of Physical Medicine and Rehabilitation, Montefiore Medical Center, Bronx, New York 10467, USA.
Am J Phys Med Rehabil. 1998 Jan-Feb;77(1):55-8; quiz 65-6. doi: 10.1097/00002060-199801000-00010.
As we learn more about the origins of coronary artery disease, research has begun to focus on its prevention. The purpose of this study was to determine if exercise stress testing of the offspring of our cardiac rehabilitation patients would be a useful adjunct to their general cardiac risk factor assessment. In addition, we sought to quantitate the number of cardiac risk factors they might have already accumulated. We determined the lifestyle and lipid profiles of 22 young, healthy subjects. Subjects underwent maximal multistage exercise stress tests. Eighty-six percent of subjects had two or more major risk factors for CAD, and 73% had contributory risk factors. Seventy-three percent of subjects also demonstrated hypercholesterolemia. Exercise testing did not induce ischemic changes on electrocardiography of any subject. Our research revealed that these offspring demonstrate an alarming number of coronary artery disease risk factors, even though exercise stress tests were negative.
随着我们对冠状动脉疾病起源的了解越来越多，研究已开始关注其预防。本研究的目的是确定对我们心脏康复患者的后代进行运动压力测试是否会成为他们一般心脏风险因素评估的有用辅助手段。此外，我们试图量化他们可能已经积累的心脏风险因素的数量。我们测定了22名年轻健康受试者的生活方式和血脂谱。受试者接受了最大多级运动压力测试。86%的受试者有两个或更多的CAD主要风险因素，73%有促成风险因素。73%的受试者还表现出高胆固醇血症。运动测试未在任何受试者的心电图上诱发缺血性改变。我们的研究表明，尽管运动压力测试结果为阴性，但这些后代显示出数量惊人的冠状动脉疾病风险因素。
