Orsnes G B, Sørensen P S
Department of Neurology, The National University Hospital, Rigshospitalet, Copenhagen, Denmark.
Acta Neurol Scand. 1998 Jan;97(1):36-40.
To test new electronic equipment, TREMOR, for quantitative registration of rest tremor and kinetic tremor of the extremities.
The tremor intensity of rest tremor and kinetic tremor was studied in 14 multiple sclerosis (MS) patients. Clonazepam was used in an open study in 11 MS patients to evaluate the sensitivity of TREMOR, compared to the clinical observations.
We found no diurnal variations in tremor. Five patients discontinued the trial because of side effects due to clonazepam. Clonazepam significantly reduced clinically rest tremor in all 6 patients and clinically kinetic tremor in 5 patients. Tested by TREMOR all patients showed significant reduction in rest tremor and kinetic tremor. Correlation between electronic assessment of kinetic tremor, clinical score and Peg board test were good.
TREMOR was found useful for assessment of the severity of tremor in patients with kinetic tremor and thereby avoid intra- and interobserver variation.
测试新型电子设备TREMOR，用于定量记录四肢的静止性震颤和运动性震颤。
对14例多发性硬化症（MS）患者的静止性震颤和运动性震颤强度进行了研究。在一项开放性研究中，对11例MS患者使用氯硝西泮，与临床观察结果相比，以评估TREMOR的敏感性。
我们发现震颤无昼夜变化。5例患者因氯硝西泮的副作用而中断试验。氯硝西泮使所有6例患者的临床静止性震颤显著减轻，5例患者的临床运动性震颤显著减轻。通过TREMOR测试，所有患者的静止性震颤和运动性震颤均显著减轻。运动性震颤的电子评估、临床评分与钉板试验之间的相关性良好。
发现TREMOR有助于评估运动性震颤患者的震颤严重程度，从而避免观察者内和观察者间的差异。
