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钙和磷酸盐对嗜铬髓质颗粒中儿茶酚胺、三磷酸腺苷和多巴胺β-羟化酶的影响。

Effects of calcium and phosphate on catecholamines, ATP and dopamine beta-hydroxylase of chromaffin medullary granules.

作者信息

Schümann H J, Althoff B

出版信息

Naunyn Schmiedebergs Arch Pharmacol. 1976;293(1):67-74. doi: 10.1007/BF00498872.

DOI:10.1007/BF00498872
PMID:948353
Abstract

Isolated bovine chromaffin granules lost their catecholamines to a significantly higher degree when incubated in isotonic sucrose-buffer of pH 7.4 containing 10 and 25 mM sodium phosphate, respectively, than during incubatation in sucrose with 4 mM sodium phosphate. 2. In 4mM sodium phosphate-sucrose, CaCl(2) in a final concentration of 1 and 2 mM, respectively, produced only traces of an amorphous precipitate of calcium phosphate which increased the efflux of catecholamines only to a small degree. The same concentrations of CaCl(2) in 10 and 25 mM sodium phosphate containing sucrose solutions caused larger amounts of calcium phosphate precipitate and simultaneously a very high efflux of catecholamines. Small amounts of exogenous ATP (1 mM) and MgCl(2) (0.3 mM) effectively antagonized the efflux of catecholamines from the granules evolked by calcium phosphate...

摘要
  1. 当分别在含有10 mM和25 mM磷酸钠的pH 7.4等渗蔗糖缓冲液中孵育时，分离出的牛嗜铬颗粒损失其儿茶酚胺的程度明显高于在含有4 mM磷酸钠的蔗糖中孵育期间。2. 在4 mM磷酸钠 - 蔗糖中，终浓度分别为1 mM和2 mM的CaCl₂仅产生微量无定形磷酸钙沉淀，这仅使儿茶酚胺外流略有增加。在含有蔗糖溶液的10 mM和25 mM磷酸钠中相同浓度的CaCl₂导致大量磷酸钙沉淀，同时儿茶酚胺外流非常高。少量外源性ATP（1 mM）和MgCl₂（0.3 mM）有效地拮抗了由磷酸钙引起的颗粒中儿茶酚胺的外流……

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本文引用的文献

1
The mechanism of catecholamine release from the adrenal medulla and the role of calcium in stimulus-secretion coupling.肾上腺髓质儿茶酚胺释放的机制以及钙在刺激-分泌偶联中的作用。
J Physiol. 1963 Jul;167(2):288-310. doi: 10.1113/jphysiol.1963.sp007150.
2
[The influence of calcium on catecholamine liberation].[钙对儿茶酚胺释放的影响]
Experientia. 1962 Mar 15;18:138-40. doi: 10.1007/BF02153862.
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ANALYSIS OF THE MG++-ATP DEPENDENT STORAGE MECHANISM IN THE AMINE GRANULES OF THE ADRENAL MEDULLA.肾上腺髓质胺颗粒中MG++依赖的ATP储存机制分析
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[Effects of insulin and reserpine on the adrenalin and ATP content of the chromatic granules of the adrenal medulla].[胰岛素和利血平对肾上腺髓质嗜铬颗粒中肾上腺素和三磷酸腺苷含量的影响]
Naunyn Schmiedebergs Arch Exp Pathol Pharmakol. 1958;233(3):237-49.
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Adenosinephosphates and inorganic phosphate in the adrenaline and noradrenaline containing granules of the adrenal medulla.肾上腺髓质含肾上腺素和去甲肾上腺素颗粒中的腺苷磷酸和无机磷酸盐。
Acta Physiol Scand. 1958 Jun 2;42(3-4):321-32. doi: 10.1111/j.1748-1716.1958.tb01566.x.
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Observations on the distribution of catechol amines and adenosinetriphosphate in the bovine adrenal medulla.牛肾上腺髓质中儿茶酚胺和三磷酸腺苷分布的观察
J Physiol. 1956 Sep 27;133(3):548-57. doi: 10.1113/jphysiol.1956.sp005607.
7
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8
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Metal-dependent aggregation of biogenic amines: a hypothesis for their storage and release.
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