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颈部畸胎瘤:产前诊断与长期随访

Cervical teratoma: prenatal diagnosis and long-term follow-up.

作者信息

Kerner B, Flaum E, Mathews H, Carlson D E, Pepkowitz S H, Hixon H, Graham J M

机构信息

Medical Genetics Birth Defects Center, Ahmanson Pediatric Center, Los Angeles, California, USA.

出版信息

Prenat Diagn. 1998 Jan;18(1):51-9.

PMID:9483640
Abstract

Cervical teratomas are rare tumours which are the result of abnormal prenatal development. They are usually detected at birth, but can occasionally remain silent until adulthood. Obstruction of the airway is the major challenge in the neonatal period. Prenatal diagnosis allows for early consultation with paediatric surgical specialists, so that the time and place of delivery can be addressed, and planning for resuscitative efforts can be organized in advance. If the airway is quickly stabilized and resection of the tumour is not delayed, the prognosis is good. Cervical teratomas in neonates are usually benign; however, malignant transformation and metastasis can occur as a rare event, influencing long-term survival and prognosis. We present two cases of neonatal cervical teratoma detected prenatally by ultrasound. In one case, termination of the pregnancy was elected. In the other case, the child was delivered at 36 weeks' gestation, an airway was secured, and subtotal resection of the tumour was performed. No developmental or neurological deficit has been detected on long-term follow-up at 5 years of age. We present a review of the literature, with attention to outcome and potential for malignancy in neonatal cervical teratomas, in order to provide help in decision-making, once prenatal diagnosis is made.

摘要

颈部畸胎瘤是一种罕见的肿瘤,是产前发育异常的结果。它们通常在出生时被发现,但偶尔也可能在成年前一直未被察觉。气道梗阻是新生儿期的主要挑战。产前诊断有助于尽早与小儿外科专家会诊,从而确定分娩时间和地点,并提前安排复苏措施。如果气道能迅速稳定且肿瘤切除不延迟,预后良好。新生儿颈部畸胎瘤通常为良性;然而,恶性转化和转移虽属罕见,但会影响长期生存和预后。我们报告两例产前经超声诊断的新生儿颈部畸胎瘤病例。其中一例选择了终止妊娠。另一例在孕36周时分娩,确保了气道通畅,并进行了肿瘤次全切除。在5岁的长期随访中未发现发育或神经功能缺陷。我们对文献进行了综述,关注新生儿颈部畸胎瘤的预后及恶变可能性,以便在做出产前诊断后为决策提供帮助。

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